N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide

Base Information

Chemical Name:N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide
CAS No.:869347-13-7
Molecular Formula:C₂₈H₄₃N₃O₅SSi₂
Molecular Weight:589.904
Hs Code.:

Synonyms:N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide

There total 14 articles about N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 869347-12-6
N⁴-benzoyl-1-[2-bromo-2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-thio-β-D-ribofuranosyl]cytosine

: 869347-13-7
N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide

Guidance literature:: With 2,2’-azobis(4-methoxy-2,4-dimethyl)valeronitrile; tri-n-butyl-tin hydride; In dichloromethane; at 20 ℃;
DOI:10.1021/jo051248f

Reference yield:

: (6aR,9aS)-2,2,4,4-tetraisopropyl-8-((4-(octyloxy)benzyl)thio)tetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocine

: C₁₄H₁₇N₃O₂Si

: 869347-13-7
N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide

: C₂₈H₄₃N₃O₅SSi₂

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1080/15257770.2020.1832694

Reference yield:

: C₂₈H₄₁N₃O₅SSi₂

: 869347-13-7
N-(2-oxo-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyltetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,2-dihydropyrimidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 3.6 g / LiBr; BF₃*OEt₂ / dioxane; diethyl ether / 50 °C

2: 95 percent / 2,2'-azobis(2,4-dimethyl-4-methoxyvaleronitrile); tributyltin hydride / CH₂Cl₂ / 20 °C

With 2,2’-azobis(4-methoxy-2,4-dimethyl)valeronitrile; boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; lithium bromide; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/jo051248f