2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid

Base Information

Chemical Name:2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid
CAS No.:917114-07-9
Molecular Formula:C₂₉H₃₁N₃O₆
Molecular Weight:517.582
Hs Code.:

Synonyms:2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid

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Chemical Property of 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid

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Technology Process of 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid

There total 13 articles about 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 927880-11-3
2'-(3-carbamoyl-phenylcarbamoyl)-4'-isopropylamino-biphenyl-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester

: 917114-07-9
2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; for 2h; Heating;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 576170-38-2
3-(tert-butyl) 1-methyl 4-hydroxyisophthalate

: 917114-07-9
2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 13.3 g / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2.1: bis(pinacolato)diboron; PPh₃; AcOK / PdCl₂(PPh₃)2 / toluene / Heating

2.2: 74 percent / Na₂CO₃ / Pd(PPh₃)2 / toluene / Heating

3.1: 72 percent / Fe; AcOH / 1 h / 60 °C

4.1: 91 percent / NaBH(OAc)3; AcOH / 24 h / 20 °C

5.1: 394 mg / H₂ / Pd/C / methanol / 12 h / 20 °C

6.1: 422 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

7.1: 69 percent / NaOH / methanol; H₂O / 2 h / Heating

With pyridine; sodium hydroxide; hydrogen; potassium acetate; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 790230-23-8
3-tert-butyl 1-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}isophthalate

: 917114-07-9
2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)-4'-(isopropylamino)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis(pinacolato)diboron; PPh₃; AcOK / PdCl₂(PPh₃)2 / toluene / Heating

1.2: 74 percent / Na₂CO₃ / Pd(PPh₃)2 / toluene / Heating

2.1: 72 percent / Fe; AcOH / 1 h / 60 °C

3.1: 91 percent / NaBH(OAc)3; AcOH / 24 h / 20 °C

4.1: 394 mg / H₂ / Pd/C / methanol / 12 h / 20 °C

5.1: 422 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

6.1: 69 percent / NaOH / methanol; H₂O / 2 h / Heating

With sodium hydroxide; hydrogen; potassium acetate; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; toluene; 1.2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071