(2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine

Base Information

Chemical Name:(2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine
CAS No.:885462-61-3
Molecular Formula:C₃₄H₄₇NO₃S₂Si
Molecular Weight:609.97
Hs Code.:

Synonyms:(2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine

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Chemical Property of (2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine

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Technology Process of (2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine

There total 1 articles about (2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: (S)-(+)-N-(4-chlorobutylidene)-p-toluenesulfinamide

: 302934-11-8
(S)-2-(Triisopropylsyloxymethyl)phenyl p-tolylsulfoxide

: 885462-61-3
(2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine

Guidance literature:: (S)-2-(Triisopropylsyloxymethyl)phenyl p-tolylsulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(S)-(+)-N-(4-chlorobutylidene)-p-toluenesulfinamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 24h;
DOI:10.1055/s-2006-926306

Reference yield: 79.0%

: 885462-61-3
(2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine

: (2R,1'S)-(1'-phenyl-1'-triisopropylsilyloxymethyl)pyrrolidine

Guidance literature:: With nickel; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1055/s-2006-926306

Reference yield:

: 885462-61-3
(2R,1'S)-N-[(S)-2-(p-tolylsulfinyl)]-2-[(2-p-tolylsulfinylphenyl)triisopropylsilyloxymethyl]pyrrolidine

: 885462-68-0
(1R,2S')-α-(pyrrolidin-2-yl)benzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / Raney-nickel / tetrahydrofuran / 2 h / 20 °C

2: 91 percent / NBu₄F / CH₂Cl₂ / 3 h / 20 °C

With tetrabutyl ammonium fluoride; nickel; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2006-926306