4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate

Base Information

• Chemical Name: 4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate
• CAS No.: 1292299-17-2
• Molecular Formula: C₁₈H₂₇O₈P
• Molecular Weight: 402.381
• Mol file: 1292299-17-2.mol

Synonyms:4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate

Chemical Property of 4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate

There total 4 articles about 4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl phosphate (598-02-7) + 4-(2-bromoacetyl)-3-methoxyphenyl pivalate (1292299-16-1) → 4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate (1292299-17-2)

Guidance literature:

With silver(l) oxide; In acetonitrile; at 60 ℃; for 16h;

DOI:10.1139/V10-143

Reference yield:

O-methylresorcine (150-19-6) → 4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate (1292299-17-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: aluminum (III) chloride / 0 °C / Inert atmosphere

3: sodium bromide / acetone / 24 h / 60 °C

4: silver(l) oxide / acetonitrile / 16 h / 60 °C

With dmap; aluminum (III) chloride; triethylamine; sodium bromide; silver(l) oxide; In dichloromethane; acetone; acetonitrile;

DOI:10.1139/V10-143

Reference yield:

3-methoxyphenyl 2,2-dimethylpropionate (97483-86-8) → 4-(2-(diethoxyphosphoryloxy)acetyl)-3-methoxyphenyl pivalate (1292299-17-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / 0 °C / Inert atmosphere

2: sodium bromide / acetone / 24 h / 60 °C

3: silver(l) oxide / acetonitrile / 16 h / 60 °C

With aluminum (III) chloride; sodium bromide; silver(l) oxide; In acetone; acetonitrile;

DOI:10.1139/V10-143

upstream raw materials:

O-methylresorcine

4-(2-chloroacetyl)-3-methoxyphenyl pivalate

Diethyl phosphate

4-(2-bromoacetyl)-3-methoxyphenyl pivalate

Downstream raw materials:

4-hydroxy-2-methoxyphenylacetic acid

diethyl (2-(4-hydroxy-2-methoxyphenyl)-2-oxoethyl)phosphate