Technology Process of 4,10,16-Trimethoxy-4,10,16-triphenyl-13-(tetrahydro-pyran-2-yloxy)-cyclooctadeca-2,5,8,11,14,17-hexayne-1,7-diol
There total 12 articles about 4,10,16-Trimethoxy-4,10,16-triphenyl-13-(tetrahydro-pyran-2-yloxy)-cyclooctadeca-2,5,8,11,14,17-hexayne-1,7-diol which
guide to synthetic route it.
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synthetic route:
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165055-43-6
4,10,16-Trimethoxy-4,10,16-triphenyl-13-(tetrahydro-pyran-2-yloxy)-cyclooctadeca-2,5,8,11,14,17-hexayne-1,7-diol
- Guidance literature:
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4-Methoxy-4-phenyl-hepta-2,5-diynedial; 2-[4-Methoxy-1-(3-methoxy-3-phenyl-penta-1,4-diynyl)-4-phenyl-hexa-2,5-diynyloxy]-tetrahydro-pyran;
With
ethylmagnesium bromide;
In
tetrahydrofuran;
at 0 ℃;
Schlenk technique;
Inert atmosphere;
With
cerium(III) chloride;
Schlenk technique;
Inert atmosphere;
DOI:10.1039/c7nj00028f
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165055-43-6
4,10,16-Trimethoxy-4,10,16-triphenyl-13-(tetrahydro-pyran-2-yloxy)-cyclooctadeca-2,5,8,11,14,17-hexayne-1,7-diol
- Guidance literature:
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Multi-step reaction with 6 steps
1: 55.5 g / tetrahydrofuran / Ambient temperature
2: 1.) BuLi / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, DMSO, rt, 15 h
3: 1.) EtMgBr / 1.) THF, 0 deg C, 30 min, 2.) THF, rt, 2 h
4: 97 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 1 h / Ambient temperature
5: 95 percent / TBAF / tetrahydrofuran; H2O / 2 h / Ambient temperature
6: 1.) EtMgBr, 2.) CeCl3 / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h
With
n-butyllithium; cerium(III) chloride; ethylmagnesium bromide; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(98)00011-8
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165055-43-6
4,10,16-Trimethoxy-4,10,16-triphenyl-13-(tetrahydro-pyran-2-yloxy)-cyclooctadeca-2,5,8,11,14,17-hexayne-1,7-diol
- Guidance literature:
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Multi-step reaction with 3 steps
1: 95 percent / PPTS / methanol / 2 h / 55 °C
2: 40 percent / Swern reagent / 0.5 h / -60 °C / other reagents, temperatures, reaction times
3: 1.) EtMgBr, 2.) CeCl3 / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h
With
cerium(III) chloride; swern reagent; ethylmagnesium bromide; pyridinium p-toluenesulfonate;
In
methanol;
DOI:10.1016/S0040-4020(98)00011-8
