benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Base Information

Chemical Name:benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate
CAS No.:1234619-70-5
Molecular Formula:C₂₉H₂₀F₃N₇O₂
Molecular Weight:555.519
Hs Code.:

Synonyms:benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

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Chemical Property of benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

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Technology Process of benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

There total 7 articles about benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1234737-79-1
(7R)-2-amino-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 501-53-1,94274-21-2
benzyl chloroformate

: 1234619-70-5
benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Guidance literature:: With pyridine; at 0 - 20 ℃; for 12h; Inert atmosphere;

Reference yield: 100.0%

: (7R)-2-amino-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile hydrochloride

: 501-53-1,94274-21-2
benzyl chloroformate

: 1234619-70-5
benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Guidance literature:: With pyridine; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/cmdc.201500269

Reference yield:

: 1234620-56-4
4-(2-cyano-3-oxobut-1-en-1-yl)benzonitrile

: 1234619-70-5
benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; rac-Pro-OH / dichloromethane; N,N-dimethyl-formamide / 192 h / 20 °C / Inert atmosphere; Molecular sieve

1.2: 1 h / Inert atmosphere; Reflux

2.1: triethylamine; pyridine / toluene / Inert atmosphere; Reflux

3.1: copper diacetate; triethylamine; pyridine / dichloromethane / 36 h / 20 °C / Molecular sieve

3.2: 36 h / 20 °C

4.1: KBD 6371 / 2-Methylpentane; ethyl acetate / 24 °C / Resolution of racemate

5.1: hydrazine hydrate / ethanol / 1 h / 85 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: pyridine / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; copper diacetate; hydrazine hydrate; triethylamine; rac-Pro-OH; In ethanol; 2-Methylpentane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: |Biginelli Pyrimidone Synthesis / 1.2: |Biginelli Pyrimidone Synthesis / 3.1: |Chan-Lam Coupling / 3.2: |Chan-Lam Coupling;
DOI:10.1002/cmdc.201500269