6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

Base Information

• Chemical Name: 6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione
• CAS No.: 133549-84-5
• Molecular Formula: C₂₇H₂₆N₄O₂S
• Molecular Weight: 470.595

Synonyms:6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

Chemical Property of 6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

Chemical Property:

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Technology Process of 6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

There total 2 articles about 6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

phenylthiomethyl chloride (7205-91-6) + 6-cyclohexyl-4,7-dihydro-2-phenyl-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8(6H)-dione (129095-32-5) → 6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione (133549-84-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; for 19h; Ambient temperature;

DOI:10.1021/jm00109a028

Reference yield:

4-Ethoxycarbonyl-1-cyclohexyl-3-hydroxy-3-pyrrolin-2-on (4563-90-0) → 6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione (133549-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / glacial acetic acid / Heating

2: 34 percent / tetrabutylammonium fluoride / tetrahydrofuran; dimethylformamide / 19 h / Ambient temperature

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00109a028

Reference yield: 65.0%

6-Cyclohexyl-2-phenyl-4-phenylsulfanylmethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione (133549-84-5) → 6-cyclohexyl-6,7-dihydro-2-phenyl-4-((phenylsulfonyl)methyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione (133549-89-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1021/jm00109a028

upstream raw materials:

phenylthiomethyl chloride

6-cyclohexyl-4,7-dihydro-2-phenyl-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8(6H)-dione

4-Ethoxycarbonyl-1-cyclohexyl-3-hydroxy-3-pyrrolin-2-on

Downstream raw materials:

6-cyclohexyl-6,7-dihydro-2-phenyl-4-((phenylsulfonyl)methyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione

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