3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide

Base Information

Chemical Name:3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide
CAS No.:200418-20-8
Molecular Formula:C₁₉H₁₅BrFN₅O₂
Molecular Weight:444.263
Hs Code.:

Synonyms:3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide

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Chemical Property of 3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide

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Technology Process of 3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide

There total 5 articles about 3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 200418-20-8
3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) KOH / 1.) THF, RT, 15 min, 2.) THF, RT, 4 h

2: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 2.5 h

3: 16.0 g / NaN₃ / dimethylformamide / 3 h / Ambient temperature

With potassium hydroxide; aluminium trichloride; sodium azide; In N,N-dimethyl-formamide;
DOI:10.1021/jm970389+

Reference yield:

: 350-28-7
3-fluoro-4-methyl-benzoic acid

: 200418-20-8
3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride, DMF / tetrahydrofuran / 0.5 h / Heating

2: sulfuryl chloride, benzoyl peroxide / benzene / 2.5 h / Heating

3: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 2.5 h

4: 16.0 g / NaN₃ / dimethylformamide / 3 h / Ambient temperature

With aluminium trichloride; sodium azide; sulfuryl dichloride; Perbenzoic acid; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm970389+

Reference yield:

: 59189-97-8
3-fluoro-4-methylbenzoic acid chloride

: 200418-20-8
3-(4-Azidomethyl-3-fluoro-benzoyl)-4-bromo-indole-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuryl chloride, benzoyl peroxide / benzene / 2.5 h / Heating

2: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 2.5 h

3: 16.0 g / NaN₃ / dimethylformamide / 3 h / Ambient temperature

With aluminium trichloride; sodium azide; sulfuryl dichloride; Perbenzoic acid; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm970389+