N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide

Base Information

• Chemical Name: N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide
• CAS No.: 1067427-56-8
• Molecular Formula: C₂₆H₂₇ClN₂O₃S
• Molecular Weight: 483.031
• Mol file: 1067427-56-8.mol

Synonyms:N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide

Chemical Property of N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide

There total 3 articles about N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

Norchlorpromazine (1225-64-5) + 3,4-dimethoxyphenylacetyl chloride (10313-60-7) → N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide (1067427-56-8)

Guidance literature:

Norchlorpromazine; With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

3,4-dimethoxyphenylacetyl chloride; With triisobutylaluminum; In 1,2-dichloro-ethane; toluene; Reflux;

DOI:10.1016/j.ejmech.2017.09.021

Reference yield:

chlorpromazine hydrochloride (69-09-0) → N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide (1067427-56-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 1 h / Reflux

2.1: 2 h / Reflux

3.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 20 °C

3.2: Reflux

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triethylamine; In 1,2-dichloro-ethane;

DOI:10.1016/j.ejmech.2017.09.021

Reference yield:

C18H18Cl2N2O2S → N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide (1067427-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2 h / Reflux

2.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 20 °C

2.2: Reflux

With triethylamine; In 1,2-dichloro-ethane;

DOI:10.1016/j.ejmech.2017.09.021

upstream raw materials:

Norchlorpromazine

3,4-dimethoxyphenylacetyl chloride

chlorpromazine hydrochloride