6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Base Information

• Chemical Name: 6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one
• CAS No.: 1454580-25-6
• Molecular Formula: C₁₉H₁₄FNO₄
• Molecular Weight: 339.323
• Mol file: 1454580-25-6.mol

Synonyms:6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Chemical Property of 6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

There total 2 articles about 6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

6-(2-chloropropanoyl)-2H-1,4-benzoxazin-3(4H)-one (293741-63-6) + p-Fluorophenylacetic acid (405-50-5) → 6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one (1454580-25-6)

Guidance literature:

6-(2-chloropropanoyl)-2H-1,4-benzoxazin-3(4H)-one; p-Fluorophenylacetic acid; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.07.043

Reference yield:

3,4-dihydro-3-oxo-2H-1,4-benzoxazine (5466-88-6) → 6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one (1454580-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 12 h / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 12 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.07.043

Reference yield: 24.0%

6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one (1454580-25-6) → 6-[2-fluoro-4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one (1454580-26-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.07.043

upstream raw materials:

6-(2-chloropropanoyl)-2H-1,4-benzoxazin-3(4H)-one

p-Fluorophenylacetic acid

3,4-dihydro-3-oxo-2H-1,4-benzoxazine

Downstream raw materials:

6-[2-fluoro-4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one