2-nitrophenyl pyridin-3-yl ketone

Base Information

• Chemical Name: 2-nitrophenyl pyridin-3-yl ketone
• CAS No.: 3882-45-9
• Molecular Formula: C₁₂H₈N₂O₃
• Molecular Weight: 228.207
• Mol file: 3882-45-9.mol

Synonyms:2-nitrophenyl pyridin-3-yl ketone

Chemical Property of 2-nitrophenyl pyridin-3-yl ketone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-nitrophenyl pyridin-3-yl ketone

There total 5 articles about 2-nitrophenyl pyridin-3-yl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2-nitrophenyl)(pyridin-3-yl)methanol (3882-44-8) → 2-nitrophenyl pyridin-3-yl ketone (3882-45-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 144h;

DOI:10.1016/j.ica.2011.10.018

Reference yield: 63.0%

→ 2-nitrophenyl pyridin-3-yl ketone (3882-45-9)

Guidance literature:

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) → 2-nitrophenyl pyridin-3-yl ketone (3882-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) THF, hexane, -70 deg C, 0.5 h, 2.) -70 deg C, 1 h

2: 0.75 g / MnO₂ / CHCl₃ / 20 h / Ambient temperature

With manganese(IV) oxide; n-butyllithium; In chloroform;

upstream raw materials:

(2-nitrophenyl)(pyridin-3-yl)methanol

3-Bromopyridine

2-nitro-benzaldehyde

Downstream raw materials:

2-aminophenyl-(3-pyridinyl)methanone

5H-indeno[1,2-b]pyridin-5-one