(S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide

Base Information

Chemical Name:(S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide
CAS No.:943778-95-8
Molecular Formula:C₃₁H₃₀N₆OS
Molecular Weight:534.685
Hs Code.:

Synonyms:(S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide

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Chemical Property of (S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide

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Technology Process of (S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide

There total 13 articles about (S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 943779-01-9
(S)-{4-[2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(1-phenyl-ethylcarbamoyl)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester

: 943778-95-8
(S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide

Guidance literature:: (S)-{4-[2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(1-phenyl-ethylcarbamoyl)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With potassium carbonate; In dichloromethane; water; ethyl acetate;

Reference yield:

: 943778-96-9
methyl 4-chloro-3-nitrobenzoate

: 943778-95-8
(S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1,4-dioxane / 90 °C

2: iron; ammonium chloride / ethanol; water / Reflux

3: acetic acid / 0.33 h / 120 °C

4: lithium hydroxide; water / tetrahydrofuran

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine

6: trifluoroacetic acid

With water; iron; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmcl.2013.04.009

Reference yield:

: 943778-99-2
4-(4-tert-butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid methyl ester

: 943778-95-8
(S)-4-(4-amino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-N-(1-phenylethyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / tetrahydrofuran

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine

3: trifluoroacetic acid

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2013.04.009