(4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester

Base Information

Chemical Name:(4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester
CAS No.:127658-22-4
Molecular Formula:C₃₉H₃₀BrNO₆
Molecular Weight:688.574
Hs Code.:

Synonyms:(4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester

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Chemical Property of (4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester

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Technology Process of (4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester

There total 1 articles about (4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 127658-22-4
(4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1016/S0040-4039(01)93793-1

Reference yield: 62.0%

: 127658-22-4
(4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester

: 127658-23-5
C₂₆H₁₉NO₅

Guidance literature:: With trimethylsilyl iodide; In chloroform; 1.) ice water bath, 30 s; 2.) rt, 22.5 h;
DOI:10.1016/S0040-4039(01)93793-1

Reference yield:

: 127658-22-4
(4R,5R)-5-(4-Benzyloxy-phenyl)-3-bromo-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester

: 121373-33-9,127708-96-7
(5S,5aS,9S)-5-(4-Benzyloxy-phenyl)-9-hydroxy-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / TMSI / CHCl₃ / 1.) ice water bath, 30 s; 2.) rt, 22.5 h

2: 1.) 3N sodium hydroxide; 2.) cobalt (II) chloride/sodium borohydride / 1.) THF

3: 50percent aquous acetic acid/sodium nitrite / 0 °C

With sodium hydroxide; sodium tetrahydroborate; trimethylsilyl iodide; acetic acid; cobalt(II) chloride; sodium nitrite; In chloroform;
DOI:10.1016/S0040-4039(01)93793-1