3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one

Base Information

Chemical Name:3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one
CAS No.:288571-70-0
Molecular Formula:C₁₈H₂₄O₂S
Molecular Weight:304.453
Hs Code.:

Synonyms:3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one

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Chemical Property of 3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one

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Technology Process of 3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one

There total 1 articles about 3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 104-95-0
(4-bromophenyl)thioanisole

: 209809-61-0
2-(2-cyanoethyl)-1-(methoxymethylene)cyclohexane

: 288571-70-0
3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one

Guidance literature:: (4-bromophenyl)thioanisole; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.75h;

2-(2-cyanoethyl)-1-(methoxymethylene)cyclohexane; In diethyl ether; at -78 ℃;
DOI:10.1016/S0968-0896(00)00079-1

Reference yield: 7.0%

: 288571-70-0
3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one

: (1R,6S,9R,12R)-12-Methoxy-9-(4-methylsulfanyl-phenyl)-10,11,13-trioxa-tricyclo[7.2.2.0^1,6]tridecane

: (1R,6S,9R,12S)-12-Methoxy-9-(4-methylsulfanyl-phenyl)-10,11,13-trioxa-tricyclo[7.2.2.0^1,6]tridecane

Guidance literature:: 3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one; With triphenyl phosphite; ozone; In dichloromethane; at -78 ℃;

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃;
DOI:10.1016/S0968-0896(00)00079-1

Reference yield:

: 288571-70-0
3-{2-[1-Methoxy-meth-(E)-ylidene]-cyclohexyl}-1-(4-methylsulfanyl-phenyl)-propan-1-one

: (1R,6S,9R,12R)-9-(4-Methanesulfonyl-phenyl)-12-methoxy-10,11,13-trioxa-tricyclo[7.2.2.0^1,6]tridecane

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₂; methylene blue / CH₂Cl₂ / -78 °C / UV-irradiation

1.2: 6.3 percent / TMSOTf / CH₂Cl₂

2.1: 78 percent / m-CPBA / CH₂Cl₂ / 0 - 20 °C

With oxygen; methylene blue; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.1: Oxidation / 1.2: Rearrangement / 2.1: Oxidation;
DOI:10.1016/S0968-0896(00)00079-1