benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate

Base Information

• Chemical Name: benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate
• CAS No.: 434343-70-1
• Molecular Formula: C₄₁H₆₄O₁₃
• Molecular Weight: 764.951

Synonyms:benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate

Chemical Property of benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate

Chemical Property:

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Technology Process of benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate

There total 15 articles about benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[((3R')-3'-{[(3R)-3-({(3'S)-3'-[(tert-butyl)diphenylsilyloxy]-4'-methylpentanoyl}oxy)butanoyl]oxy}-5'-methylhexanoyl)oxy]-4-methylpentanoyl}oxy)butanoyl]oxy}-5-met... (434343-69-8) → benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate (434343-70-1)

Guidance literature:

With pyridine hydrogenfluoride; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1

Reference yield:

methyl 5-methyl-3-oxohexanoate (30414-55-2) → benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate (434343-70-1)

Guidance literature:

Multi-step reaction with 10 steps

1: 96 percent / H₂ / [Ru((R)-binap)Cl₂] / methanol / 72 h / 20 °C / 76000 Torr

2: 74 percent / KOH / ethanol / 24 h / 0 - 20 °C

3: 93 percent / NaHCO₃ / dimethylformamide / 24 h / 20 °C

4: 77 percent / pyridine / CH₂Cl₂ / -78 °C

5: 95 percent / 70 percent HF*pyridine / CH₂Cl₂ / 0.33 h / 0 °C

6: 89 percent / pyridine / CH₂Cl₂ / -78 °C

7: 83 percent / H₂ / 10 percent Pd/C / methanol / 28 h

8: (COCl)2; DMF / CH₂Cl₂ / 20 °C

9: pyridine / CH₂Cl₂ / -78 - 20 °C

10: 95 percent / 70 percent HF*pyridine / CH₂Cl₂ / 0.33 h / 0 °C

With pyridine; potassium hydroxide; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; pyridine hydrogenfluoride; N,N-dimethyl-formamide; palladium on activated charcoal; RuCl₂[S-BINAP]; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1

Reference yield:

Methyl 4-methyl-3-oxopentanoate (42558-54-3) → benzyl (3R)-3-{[(3'R)-3'-{[(3S)-3-{[(3R')-3'-{[(3R)-3-{[(3'S)-3'-hydroxy-4'-methylpentanoyl]oxy}butanoyl]oxy}-5'-methylhexanoyl]oxy}-4-methylpentanoyl]oxy}butanoyl]oxy}-5-methylhexanoate (434343-70-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 89 percent / H₂ / [Ru((R)-binap)Cl₂] / methanol / 72 h / 20 °C / 76000 Torr

2: imidazole; DMAP / dimethylformamide / 18 h / 20 °C

3: KOH / ethanol / 12 h / 0 - 20 °C

4: (COCl)2; DMF / CH₂Cl₂ / 20 °C

5: 89 percent / pyridine / CH₂Cl₂ / -78 °C

6: 83 percent / H₂ / 10 percent Pd/C / methanol / 28 h

7: (COCl)2; DMF / CH₂Cl₂ / 20 °C

8: pyridine / CH₂Cl₂ / -78 - 20 °C

9: 95 percent / 70 percent HF*pyridine / CH₂Cl₂ / 0.33 h / 0 °C

With pyridine; 1H-imidazole; dmap; potassium hydroxide; oxalyl dichloride; hydrogen; pyridine hydrogenfluoride; N,N-dimethyl-formamide; palladium on activated charcoal; RuCl₂[S-BINAP]; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1

upstream raw materials:

benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[((3R')-3'-{[(3R)-3-({(3'S)-3'-[(tert-butyl)diphenylsilyloxy]-4'-methylpentanoyl}oxy)butanoyl]oxy}-5'-methylhexanoyl)oxy]-4-methylpentanoyl}oxy)butanoyl]oxy}-5-met...

methyl 5-methyl-3-oxohexanoate

Methyl 4-methyl-3-oxopentanoate

2,2-dimethyl-5-(3-methylbutanoyl)-1,3-dioxane-4,6-dione

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