(3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol

Base Information

Chemical Name:(3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol
CAS No.:184481-17-2
Molecular Formula:C₃₁H₄₄O₂Si
Molecular Weight:476.775
Hs Code.:

Synonyms:(3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol

Suppliers and Price of (3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol

There total 8 articles about (3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 917-54-4
methyllithium

: 184481-15-0
(3S,3aS,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-7a-methyl-3-(2-methyl-propenyl)-octahydro-inden-4-one

: 184481-17-2
(3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol

Guidance literature:: In diethyl ether; at -20 - -5 ℃; for 1h;
DOI:10.1021/jo961605+

Reference yield:

: 57356-77-1
4-acetoxy-3-methyl-2-cyclohexen-1-one

: 184481-17-2
(3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 40 percent / Tris-HCl buffer, pH 7, PLE, 0.1 M NaOH / dimethylsulfoxide; H₂O / 26 h / Ambient temperature

2: 89 percent / Na₂CO₃ / methanol / 1.5 h / Ambient temperature

3: 1.2 g / imidazole / dimethylformamide / 15 h / Ambient temperature

4: 1.) CuBr*Me₂S, HMPA, TMSCl, 2.) NH₄Cl, NH₄OH, pH 8-9 / 1.) THF, -78 deg C, 3 h; -78 deg C to -50 deg C, 2.5 h, 2.) H₂O, Et₂O

5: 82 percent / 80percent CF₃COOH / dioxane; H₂O / 16.5 h / 80 °C

6: 1.) TMSBr, BF₃*Et₂O, 2.) NH₄Cl, NH₄OH, pH 8-9 / 1.) THF, -78 deg C, 6.5 h, 2.) H₂O, room temperature

7: 80 percent / diethyl ether / 1 h / -20 - -5 °C

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; sodium hydroxide; chloro-trimethyl-silane; Tris-HCl buffer; copper(I) bromide dimethylsulfide complex; trimethylsilyl bromide; boron trifluoride diethyl etherate; sodium carbonate; ammonium chloride; trifluoroacetic acid; In 1,4-dioxane; methanol; diethyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo961605+

Reference yield:

: 136611-26-2
(S)-4-<(t-butyldiphenylsilyl)oxy>-3-methyl-2-cyclohexenone

: 184481-17-2
(3S,3aS,4R,7S,7aS)-7-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-3-(2-methyl-propenyl)-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) CuBr*Me₂S, HMPA, TMSCl, 2.) NH₄Cl, NH₄OH, pH 8-9 / 1.) THF, -78 deg C, 3 h; -78 deg C to -50 deg C, 2.5 h, 2.) H₂O, Et₂O

2: 82 percent / 80percent CF₃COOH / dioxane; H₂O / 16.5 h / 80 °C

3: 1.) TMSBr, BF₃*Et₂O, 2.) NH₄Cl, NH₄OH, pH 8-9 / 1.) THF, -78 deg C, 6.5 h, 2.) H₂O, room temperature

4: 80 percent / diethyl ether / 1 h / -20 - -5 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; trimethylsilyl bromide; boron trifluoride diethyl etherate; ammonium chloride; trifluoroacetic acid; In 1,4-dioxane; diethyl ether; water;
DOI:10.1021/jo961605+