3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid

Base Information

Chemical Name:3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid
CAS No.:1345962-45-9
Molecular Formula:C₁₇H₁₅N₃O₇
Molecular Weight:373.322
Hs Code.:

Synonyms:3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid

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Chemical Property of 3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid

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Technology Process of 3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid

There total 9 articles about 3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.5%

: 5-(2-carboxyvinyl)-3-hydroxy-2-methylisonicotinic acid

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1345962-45-9
3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid

Guidance literature:: 4-amino-benzoic acid; With hydrogenchloride; sodium carbonate; sodium nitrite; In water; at 0 ℃;

5-(2-carboxyvinyl)-3-hydroxy-2-methylisonicotinic acid; With sodium hydroxide; In water; at 0 - 25 ℃; for 1h; pH=10 - 11;
DOI:10.1016/j.bmc.2013.01.073

Reference yield: 24.5%

: 1345962-45-9
3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid

Guidance literature:: With hydrogenchloride; sodium carbonate; sodium nitrite; In water; at 0 ℃;

With sodium hydroxide; In water; pH=10 - 11;

Reference yield:

: 65-23-6
5-hydroxy-6-methyl-3,4-pyridinedimethanol

: 1345962-45-9
3-(2-carboxyethyl)-2-((4-carboxyphenyl)diazenyl)-5-hydroxy-6-methylisonicotinic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / 30 h / 20 °C

2.1: dipyridinium dichromate / dichloromethane

3.1: sodium hydride / tetrahydrofuran / 0.08 h

3.2: 1 h

4.1: potassium hydroxide / water; methanol / 3 h / 20 °C

5.1: hydrogenchloride; water / methanol / 48 h

6.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere

7.1: Oxone / N,N-dimethyl-formamide; acetonitrile / 3 h

8.1: hydrogenchloride; sodium nitrite; sodium carbonate / water / 0 °C

8.2: 1 h / 0 - 25 °C / pH 10 - 11

With hydrogenchloride; manganese(IV) oxide; Oxone; dipyridinium dichromate; water; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmc.2013.01.073