2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

Chemical Name:2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide
CAS No.:1566584-16-4
Molecular Formula:C₂₃H₂₇N₅O
Molecular Weight:389.5
Hs Code.:

Synonyms:2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

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Chemical Property of 2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

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Technology Process of 2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

There total 10 articles about 2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1566585-37-2
tert-butyl (1-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-methylpyrimidin-2-yl)amino)phenyl)ethyl)carbamate

: 1566584-16-4
2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1566584-16-4
2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / methanol / 0.33 h / 20 °C

1.2: 48 h

2.1: triethylamine / dichloromethane / 21 h / 20 °C

3.1: palladium; hydrogen / ethyl acetate / 3 h

4.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 6 h / 105 °C / Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With ammonium acetate; hydrogen; palladium diacetate; caesium carbonate; palladium; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate;

Reference yield:

: 42142-15-4
1-(4-nitro-phenyl)-ethylamine

: 1566584-16-4
2-(2-(2-(2-((4-(1-aminoethyl)phenyl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 21 h / 20 °C

2: palladium; hydrogen / ethyl acetate / 3 h

3: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 6 h / 105 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With hydrogen; palladium diacetate; caesium carbonate; palladium; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; ethyl acetate;