4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester

Base Information

Chemical Name:4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester
CAS No.:123417-25-4
Molecular Formula:C₂₁H₂₅NO₇
Molecular Weight:403.432
Hs Code.:

Synonyms:4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester

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Chemical Property of 4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester

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Technology Process of 4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester

There total 12 articles about 4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 120262-89-7,120329-60-4,123484-67-3,123484-69-5,144540-92-1
(5S,7R,15S)-2,2-Dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-ol

: 62-23-7
4-nitro-benzoic acid

: 123417-25-4
4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester

Guidance literature:: With diethylazodicarboxylate;

Reference yield:

: 3123-97-5
dihydro-5,5-dimethyl-2(3H)-furanone

: 123417-25-4
4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) t-butyl-lithium / 1.) THF, -70 to 0 deg C, 2.) -70 deg C

2: 80 percent / bromine / diethyl ether / 1 h / -35 °C

3: 40percent aq. HF / acetonitrile

4: 88 percent / NaBH₄, CeCl₃ / methanol / -70 °C

5: 8 percent / diethyl azodicarboxylate

With sodium tetrahydroborate; cerium(III) chloride; hydrogen fluoride; bromine; tert.-butyl lithium; diethylazodicarboxylate; In methanol; diethyl ether; acetonitrile;

Reference yield:

: 3750-41-2
2,3-dimethyl-2,3-dihydrofuran

: 123417-25-4
4-Nitro-benzoic acid (5S,7R,15R)-2,2-dimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-15-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: t-butyl-lithium / tetrahydrofuran / 0.5 h / -20 °C

2: 2.) camphorsulphonic acid / 1.) THF, -60, 2.) CH₂Cl₂, 20 deg C, 2 h

3: 88 percent / NaBH₄, CeCl₃ / methanol / -70 °C

4: 8 percent / diethyl azodicarboxylate

With sodium tetrahydroborate; cerium(III) chloride; camphor-10-sulfonic acid; tert.-butyl lithium; diethylazodicarboxylate; In tetrahydrofuran; methanol;