3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol

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Chemical Name:3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol
CAS No.:644968-49-0
Molecular Formula:C₃₄H₆₅N₃O₈
Molecular Weight:643.905
Hs Code.:

Synonyms:3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol

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Chemical Property of 3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol

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Technology Process of 3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol

There total 6 articles about 3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 644968-44-5
3-[[3-(3-{(3-{3-[bis-(2-tert-butoxycarbonyl-ethyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

: 644968-49-0
3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jo035072y

Reference yield:

: 644968-39-8
3-{(3-hydroxy-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propan-1-ol

: 644968-49-0
3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / NaOH / H₂O / 15 h / 20 °C

2: H₂ / Raney Co / methanol; H₂O / 1 h / 70 °C / 30400 Torr

3: 1.62 g / methanol / 6 h

4: 97 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; Raney Co; In tetrahydrofuran; methanol; water; 1: Michael addition / 3: Michael addition;
DOI:10.1021/jo035072y

Reference yield:

: 644968-17-2
3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

: 644968-49-0
3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 84.8 percent / H₂ / Pd/C / ethyl acetate / 120 h / 20 °C

2: 91 percent / diisopropyl azidodicarboxylate; PPh₃ / tetrahydrofuran / 0.25 h / 80 °C

3: 99 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

4: 90 percent / NaOH / H₂O / 15 h / 20 °C

5: H₂ / Raney Co / methanol; H₂O / 1 h / 70 °C / 30400 Torr

6: 1.62 g / methanol / 6 h

7: 97 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; Raney Co; In tetrahydrofuran; methanol; water; ethyl acetate; 2: Mitsunobu reaction / 4: Michael addition / 6: Michael addition;
DOI:10.1021/jo035072y