(2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

Base Information

Chemical Name:(2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one
CAS No.:1392506-43-2
Molecular Formula:C₂₉H₃₀N₄O₂
Molecular Weight:466.583
Hs Code.:

Synonyms:(2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

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Chemical Property of (2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

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Technology Process of (2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

There total 5 articles about (2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392506-40-9
benzhydrylidene aza-glycinyl-D-phenylalanine tert-butyl ester

: 1392506-43-2
(2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

: (2’S)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 2 °C / Inert atmosphere

2.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C / Inert atmosphere

3.1: tetrahydrofuran / 1.5 h / -15 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: sodium hydride / acetonitrile; mineral oil / 2 h / Inert atmosphere

With 4-methyl-morpholine; potassium tert-butylate; sodium hydride; In tetrahydrofuran; dichloromethane; acetonitrile; mineral oil;
DOI:10.1021/ol302021n

Reference yield:

: C₂₃H₂₁N₃O₃*C₂HF₃O₂

: 1392506-43-2
(2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

: (2’S)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C / Inert atmosphere

2.1: tetrahydrofuran / 1.5 h / -15 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / acetonitrile; mineral oil / 2 h / Inert atmosphere

With 4-methyl-morpholine; potassium tert-butylate; sodium hydride; In tetrahydrofuran; acetonitrile; mineral oil;
DOI:10.1021/ol302021n

Reference yield:

: C₂₈H₂₉N₃O₅

: 1392506-43-2
(2’R)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

: (2’S)-1-((diphenylmethylene)amino)-3-(3'-phenyl-N'-isopropyl-2’-propionamide)-4-methylene-imidazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1.5 h / -15 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / acetonitrile; mineral oil / 2 h / Inert atmosphere

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; acetonitrile; mineral oil;
DOI:10.1021/ol302021n