Cyclobutanecarboxylic acid, 1-amino-2-phenyl-, (1R,2R)-rel- (9CI)

Base Information

Chemical Name:Cyclobutanecarboxylic acid, 1-amino-2-phenyl-, (1R,2R)-rel- (9CI)
CAS No.:740733-77-1
Molecular Formula:C₁₁H₁₃NO₂
Molecular Weight:191.23
Hs Code.:
Mol file:740733-77-1.mol

Synonyms:Cyclobutanecarboxylic acid, 1-amino-2-phenyl-, (1R,2R)-rel- (9CI)

Suppliers and Price of Cyclobutanecarboxylic acid, 1-amino-2-phenyl-, (1R,2R)-rel- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of Cyclobutanecarboxylic acid, 1-amino-2-phenyl-, (1R,2R)-rel- (9CI)

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Cyclobutanecarboxylic acid, 1-amino-2-phenyl-, (1R,2R)-rel- (9CI)

There total 4 articles about Cyclobutanecarboxylic acid, 1-amino-2-phenyl-, (1R,2R)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,2S)-1-Benzyloxycarbonylamino-2-phenyl-cyclobutanecarboxylic acid

: 740733-77-1
(1S,2S)-1-Amino-2-phenyl-cyclobutanecarboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; at 20 ℃;
DOI:10.1016/j.tetasy.2005.10.015

Reference yield:

: 1-(ethoxycarbonyl)-2-phenylcyclobutylisocyanide

: 740733-77-1
(1S,2S)-1-Amino-2-phenyl-cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrochloric acid / tetrahydrofuran

1.2: 75 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

2.1: 92 percent / sodium hydroxide / H₂O / Heating

3.1: hydrogen / palladium on carbon / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1016/j.tetasy.2005.10.015

Reference yield:

: (1S,2S)-1-Benzyloxycarbonylamino-2-phenyl-cyclobutanecarboxylic acid ethyl ester

: 740733-77-1
(1S,2S)-1-Amino-2-phenyl-cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / sodium hydroxide / H₂O / Heating

2: hydrogen / palladium on carbon / 20 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In water;
DOI:10.1016/j.tetasy.2005.10.015