p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside

Base Information

Chemical Name:p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside
CAS No.:1415218-17-5
Molecular Formula:C₅₁H₆₃N₃O₁₂SSi
Molecular Weight:970.226
Hs Code.:

p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside

Synonyms:p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside

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Chemical Property of p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside

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Technology Process of p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside

There total 4 articles about p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242437-13-3
p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-1-thio-β-D-glucopyranoside

: 1415218-17-5
p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver trifluoromethanesulfonate / dichloromethane; diethyl ether / 0.08 h / -78 °C / Inert atmosphere; Molecular sieve

1.2: 0.08 h / -78 °C / Inert atmosphere

1.3: 2 h / -78 - 0 °C / Inert atmosphere

2.1: magnesium methanolate / dichloromethane; methanol / -20 - 0 °C / Inert atmosphere

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 20 °C / Inert atmosphere

With dmap; silver trifluoromethanesulfonate; magnesium methanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1002/anie.201205601

Reference yield:

: 1242437-11-1
p-tolyl 2-O-benzoyl-3-O-benzyl-6-O-p-methoxybenzyl-1-thio-α-L-idopyranoside

: 1415218-17-5
p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver trifluoromethanesulfonate / dichloromethane; diethyl ether / 0.08 h / -78 °C / Inert atmosphere; Molecular sieve

1.2: 0.08 h / -78 °C / Inert atmosphere

1.3: 2 h / -78 - 0 °C / Inert atmosphere

2.1: magnesium methanolate / dichloromethane; methanol / -20 - 0 °C / Inert atmosphere

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 20 °C / Inert atmosphere

With dmap; silver trifluoromethanesulfonate; magnesium methanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1002/anie.201205601

Reference yield:

: 1242437-16-6
p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-2-O-benzoyl-3-O-benzyl-6-O-p-methoxybenzyl-1-thio-α-L-idopyranoside

: 1415218-17-5
p-tolyl 2-azido-3-O-benzyl-4-O-tert-butyl-dimethylsilyl-6-O-levulinoyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium methanolate / dichloromethane; methanol / -20 - 0 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 20 °C / Inert atmosphere

With dmap; magnesium methanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; water;
DOI:10.1002/anie.201205601