di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate

Base Information

Chemical Name:di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate
CAS No.:154308-30-2
Molecular Formula:C₃₅H₃₈N₂O₇
Molecular Weight:598.696
Hs Code.:

Synonyms:di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate

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Chemical Property of di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate

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Technology Process of di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate

There total 8 articles about di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 541-16-2
t-butyl malonate

: 154308-27-7
ethyl 1-benzyl-1,2-dihydro-4-methoxy-2-oxo-6-(2-quinolinyl)pyridine-3-carboxylate

: 154308-30-2
di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate

Guidance literature:: With sodium hydride; In 1,4-dioxane; for 3.5h; Heating;
DOI:10.1002/jhet.5570300311

Reference yield:

: 96057-59-9
ethyl 3-oxo-3-(quinolin-2-yl)propanoate

: 154308-30-2
di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate

Guidance literature:: Multi-step reaction with 7 steps

1: formic acid / benzene / Heating

2: H₂, NaBH₄ / 10percent Pd/C / methanol / 18 h / 735.5 Torr

3: 79 percent / dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 0.5 h / Ambient temperature

4: EtONa / ethanol / 3 h / Ambient temperature

5: 80 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / dioxane / 1.5 h / Heating

6: 85 percent / K₂CO₃ / acetone / 1 h / Heating

7: 77 percent / NaH / dioxane / 3.5 h / Heating

With sodium tetrahydroborate; formic acid; hydrogen; sodium ethanolate; sodium hydride; potassium carbonate; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; acetone; benzene;
DOI:10.1002/jhet.5570300311

Reference yield:

: 3-[(Z)-Benzylimino]-3-quinolin-2-yl-propionic acid ethyl ester

: 154308-30-2
di-tert-butyl <1-benzyl-1,2-dihydro-3-ethoxycarbonyl-2-oxo-6-(2-quinolinyl)pyridin-4-yl>malonate

Guidance literature:: Multi-step reaction with 6 steps

1: H₂, NaBH₄ / 10percent Pd/C / methanol / 18 h / 735.5 Torr

2: 79 percent / dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 0.5 h / Ambient temperature

3: EtONa / ethanol / 3 h / Ambient temperature

4: 80 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / dioxane / 1.5 h / Heating

5: 85 percent / K₂CO₃ / acetone / 1 h / Heating

6: 77 percent / NaH / dioxane / 3.5 h / Heating

With sodium tetrahydroborate; hydrogen; sodium ethanolate; sodium hydride; potassium carbonate; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; acetone;
DOI:10.1002/jhet.5570300311