6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide

Base Information

Chemical Name:6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide
CAS No.:1438844-40-6
Molecular Formula:C₃₁H₂₉FN₄O₃S
Molecular Weight:556.661
Hs Code.:

Synonyms:6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide

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Chemical Property of 6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide

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Technology Process of 6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide

There total 8 articles about 6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438844-63-3
2-bromo-6-(4-fluorophenyl)-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide

: 1438844-72-4
5-bromo-2-methoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide

: 1438844-40-6
6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide

Guidance literature:: 5-bromo-2-methoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide; With potassium acetate; iron; cyclopentyl(diphenyl)phosphane; palladium dichloride; In 1,4-dioxane; dichloromethane; at 100 ℃; for 1h; Inert atmosphere;

2-bromo-6-(4-fluorophenyl)-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide; With water; iron; caesium carbonate; cyclopentyl(diphenyl)phosphane; palladium dichloride; In 1,4-dioxane; dichloromethane; at 125 ℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 704-45-0
2-methoxy-4-methylbenzoic acid

: 1438844-40-6
6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2.1: bromine; acetic acid / 2 h / 0 °C

3.1: cyclopentyl(diphenyl)phosphane; palladium dichloride; potassium acetate; iron / dichloromethane; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

3.2: 0.67 h / 125 °C / Inert atmosphere; Microwave irradiation

With bromine; potassium acetate; iron; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; cyclopentyl(diphenyl)phosphane; palladium dichloride; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 1438844-40-6
6-(4-fluorophenyl)-2-{4-methoxy-2-methyl-5-[(2-phenylpropan-2-yl)carbamoyl]phenyl}-N-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; toluene-4-sulfonic acid / 2 h / 20 °C

2.1: ethanol / 15 h / 75 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 15 h / 20 °C

3.2: pH Ca_. 3

4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

5.1: cyclopentyl(diphenyl)phosphane; palladium dichloride; potassium acetate; iron / dichloromethane; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

5.2: 0.67 h / 125 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; water; potassium acetate; iron; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; HATU; cyclopentyl(diphenyl)phosphane; sodium hydroxide; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;