Technology Process of 2-((3-fluorophenoxy)methyl)-6-(5-fluoropyridin-2-yl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
There total 15 articles about 2-((3-fluorophenoxy)methyl)-6-(5-fluoropyridin-2-yl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine;
In
toluene;
at 120 ℃;
for 16h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jm500259z
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium tert-butylate / N,N-dimethyl-formamide / 60 h / 2 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / ethanol / 1 h / 150 °C / Inert atmosphere; Microwave irradiation
3: ozone / methanol; dichloromethane; acetone / -78 - 20 °C / Cooling with ice
4: sodium tetrahydroborate / 1 h / 0 °C / Inert atmosphere
5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
6: ammonium cerium (IV) nitrate / water; acetonitrile / 0.25 h / Inert atmosphere
7: copper(l) iodide; N,N`-dimethylethylenediamine; potassium carbonate / toluene / 16 h / 120 °C / Inert atmosphere; Microwave irradiation
With
sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); ammonium cerium (IV) nitrate; di-isopropyl azodicarboxylate; potassium tert-butylate; potassium carbonate; caesium carbonate; ozone; triphenylphosphine; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jm500259z
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / ethanol / 1 h / 150 °C / Inert atmosphere; Microwave irradiation
2: ozone / methanol; dichloromethane; acetone / -78 - 20 °C / Cooling with ice
3: sodium tetrahydroborate / 1 h / 0 °C / Inert atmosphere
4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
5: ammonium cerium (IV) nitrate / water; acetonitrile / 0.25 h / Inert atmosphere
6: copper(l) iodide; N,N`-dimethylethylenediamine; potassium carbonate / toluene / 16 h / 120 °C / Inert atmosphere; Microwave irradiation
With
sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); ammonium cerium (IV) nitrate; di-isopropyl azodicarboxylate; potassium carbonate; caesium carbonate; ozone; triphenylphosphine; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jm500259z
