(3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one

Base Information

Chemical Name:(3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one
CAS No.:1335029-09-8
Molecular Formula:C₁₉H₂₆O₅
Molecular Weight:334.412
Hs Code.:

Synonyms:(3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one

Suppliers and Price of (3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one

There total 8 articles about (3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₄₂O₅Si

: 1335029-09-8
(3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; sodium hydrogencarbonate / dichloromethane / 12 h

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201101741

Reference yield:

: C₁₉H₂₈O₅

: 1335029-09-8
(3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; sodium hydrogencarbonate; In dichloromethane; for 12h;
DOI:10.1002/anie.201101741

Reference yield:

: 1335028-91-5
(2R,5S)-2-(benzyloxy)-7-methyloct-7-ene-1,5-diol

: 1335029-09-8
(3R,6S)-3-(benzyloxy)-6-(((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)methyl)tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 12 h

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 - -40 °C

2.2: 12 h / -40 - 25 °C

3.1: 1H-imidazole; dmap / dichloromethane / 3 h

4.1: AD-mix-β; water / tert-butyl alcohol / 24 h / 0 °C

5.1: pyridinium p-toluenesulfonate / dichloromethane / 2.5 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h

7.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; sodium hydrogencarbonate / dichloromethane / 12 h

With 1H-imidazole; dmap; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; AD-mix-β; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol; 4.1: Sharpless dihydroxylation;
DOI:10.1002/anie.201101741