3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene

Base Information

Chemical Name:3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene
CAS No.:1244022-75-0
Molecular Formula:C₄₀H₄₅N₂O₅P
Molecular Weight:664.781
Hs Code.:

Synonyms:3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene

There total 5 articles about 3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1244022-73-8
3-((4,4'-dimethoxytrityl)oxymethyl)-5-(hydroxymethyl)-1-ethynylbenzene

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1244022-75-0
3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c0cc04979d

Reference yield:

: 99-27-4
dimethyl 5-aminoisophthalate

: 1244022-75-0
3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / 12 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

3.2: Cooling with ice; Inert atmosphere

4.1: pyridine / 12 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With piperidine; pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium nitrite; In tetrahydrofuran; water; 2.1: Sonogashira coupling;
DOI:10.1039/c0cc04979d

Reference yield:

: 3,5-bis(hydroxymethyl)ethynylbenzene

: 1244022-75-0
3-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxymethyl]-5-((4,4'-dimethoxytrityl)oxymethyl)-1-ethynylbenzene

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 12 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1039/c0cc04979d