1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole

Base Information

Chemical Name:1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole
CAS No.:210564-73-1
Molecular Formula:C₄₀H₅₇ClN₄O₆
Molecular Weight:725.369
Hs Code.:

1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole

Synonyms:1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole

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Chemical Property of 1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole

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Technology Process of 1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole

There total 6 articles about 1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3598-13-8
(4-chlorophenoxy)acetonitrile

: 210564-73-1
1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) MeONa / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 3 h

2: 53 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h / Ambient temperature

3: 1.) NaH, 2.) KI / 1.) DMF, RT, 30 min, 2.) DMF, 80 deg C, 3 h

4: 78 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature

5: 1.) NaH, 2.) K₂CO₃, KI / 1.) DMF, RT, 30 min, 2.) DMF, 80 deg C, 3 h

With hydrogen; sodium methylate; sodium hydride; potassium carbonate; triphenylphosphine; potassium iodide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm9706630

Reference yield:

: 2,3-diamino-phenol; dihydrochloride

: 210564-73-1
1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) MeONa / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 3 h

2: 53 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h / Ambient temperature

3: 1.) NaH, 2.) KI / 1.) DMF, RT, 30 min, 2.) DMF, 80 deg C, 3 h

4: 78 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature

5: 1.) NaH, 2.) K₂CO₃, KI / 1.) DMF, RT, 30 min, 2.) DMF, 80 deg C, 3 h

With hydrogen; sodium methylate; sodium hydride; potassium carbonate; triphenylphosphine; potassium iodide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm9706630

Reference yield:

: 193629-08-2
2-(4-Chloro-phenoxymethyl)-1H-benzoimidazol-4-ol

: 210564-73-1
1-{3-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]propyl}oxy)benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h / Ambient temperature

2: 1.) NaH, 2.) KI / 1.) DMF, RT, 30 min, 2.) DMF, 80 deg C, 3 h

3: 78 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature

4: 1.) NaH, 2.) K₂CO₃, KI / 1.) DMF, RT, 30 min, 2.) DMF, 80 deg C, 3 h

With hydrogen; sodium hydride; potassium carbonate; triphenylphosphine; potassium iodide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm9706630