Technology Process of 4-(3,4-dimethoxybenzyl)hex-5-enoic acid
There total 5 articles about 4-(3,4-dimethoxybenzyl)hex-5-enoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
ethanol; water;
at 95 ℃;
for 12h;
DOI:10.1021/jo960829p
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / 0 °C
2: 1.) pyrrolidine, K2CO3 / 1.) C6H6, room temp., 3 h, 2.) CH3CN, 105 deg C, 24 h
3: 1.) n-BuLi / 1.) THF, rom temp., 30 min, 2.) THF, 2 h
4: KOH / ethanol; H2O / 12 h / 95 °C
With
pyrrolidine; potassium hydroxide; n-butyllithium; potassium carbonate; pyridinium chlorochromate;
In
ethanol; dichloromethane; water;
DOI:10.1021/jo960829p
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / BH3*SMe2 / diethyl ether; tetrahydrofuran / 1.5 h / 75 °C
2: 80 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / 0 °C
3: 1.) pyrrolidine, K2CO3 / 1.) C6H6, room temp., 3 h, 2.) CH3CN, 105 deg C, 24 h
4: 1.) n-BuLi / 1.) THF, rom temp., 30 min, 2.) THF, 2 h
5: KOH / ethanol; H2O / 12 h / 95 °C
With
pyrrolidine; potassium hydroxide; n-butyllithium; dimethylsulfide borane complex; potassium carbonate; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo960829p
