N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid]

Base Information

• Chemical Name: N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid]
• CAS No.: 159236-37-0
• Molecular Formula: C₂₅H₂₃N₃O₆
• Molecular Weight: 461.474
• Mol file: 159236-37-0.mol

Synonyms:N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid]

Chemical Property of N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid]

There total 5 articles about N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

dimethyl N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoate] → N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid] (159236-37-0)

Guidance literature:

With sodium hydroxide; In methanol; at -5 - 20 ℃; for 15h;

DOI:10.1134/S1070363216010254

Reference yield: 53.0%

Nα-dinicotinoyl-bis-L-phenylalanine ethyl ester (159236-36-9) → N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid] (159236-37-0)

Guidance literature:

With potassium hydroxide; In methanol; at -5 ℃; for 3h;

DOI:10.1135/cccc19941451

Reference yield:

3,5-Pyridinedicarboxylic acid (499-81-0) → N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid] (159236-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / dioxane / 1 h / Heating

2: 67 percent / Et₃N / benzene; CH₂Cl₂ / 3 h / -5 °C / pH 8

3: 53 percent / KOH / methanol / 3 h / -5 °C

With potassium hydroxide; thionyl chloride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; benzene;

DOI:10.1135/cccc19941451

upstream raw materials:

3,5-Pyridinedicarboxylic acid

L-phenylalanine

N^α-dinicotinoyl-bis-L-phenylalanine ethyl ester

pyridine-3,5-dicarbonyl dichloride