2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate

Base Information

Chemical Name:2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate
CAS No.:1616288-98-2
Molecular Formula:C₂₉H₃₂ClN₃O₄
Molecular Weight:522.044
Hs Code.:

Synonyms:2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate

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Chemical Property of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate

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Technology Process of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate

There total 16 articles about 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1303445-99-9
2-(benzyloxy)-3-(chloromethyl)-4,6-dimethylpyridine

: 1616288-97-1
(8-chloro-1-oxo-3,4-dihydro-2H-isoquinolin-7-yl) N,N-diethylcarbamate

: 1616288-98-2
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate

Guidance literature:: (8-chloro-1-oxo-3,4-dihydro-2H-isoquinolin-7-yl) N,N-diethylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

2-(benzyloxy)-3-(chloromethyl)-4,6-dimethylpyridine; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;

Reference yield:

: 53475-53-9
2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile

: 1616288-98-2
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

2.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; thionyl chloride; sodium hydride; diisobutylaluminium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 1616288-98-2
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl diethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver(l) oxide / toluene / 20 h / 110 °C

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

4.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; thionyl chloride; sodium hydride; diisobutylaluminium hydride; silver(l) oxide; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;