methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate

Base Information

Chemical Name:methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate
CAS No.:159111-92-9
Molecular Formula:C₁₈H₂₁NO₄
Molecular Weight:315.369
Hs Code.:

Synonyms:methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate

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Chemical Property of methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate

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Technology Process of methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate

There total 5 articles about methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-(S)-2-(Acryloyl-benzyl-amino)-6-triethylsilanyloxy-hepta-4,6-dienoic acid methyl ester

: 159111-92-9
methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate

Guidance literature:: With potassium fluoride; In methanol; Yield given; Heating;
DOI:10.1016/S0040-4039(00)78176-7

Reference yield:

: 159111-90-7
(S)-2-(Acryloyl-benzyl-amino)-4-oxo-butyric acid methyl ester

: 159111-92-9
methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / NaH, / tetrahydrofuran / 0 °C

2: Et₃N / CD₂Cl₂ / 1 h / Ambient temperature

3: KF / methanol / Heating

With potassium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane-d2;
DOI:10.1016/S0040-4039(00)78176-7

Reference yield:

: 159111-91-8
(E)-(S)-2-(Acryloyl-benzyl-amino)-6-oxo-hept-4-enoic acid methyl ester

: 159111-92-9
methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CD₂Cl₂ / 1 h / Ambient temperature

2: KF / methanol / Heating

With potassium fluoride; triethylamine; In methanol; dichloromethane-d2;
DOI:10.1016/S0040-4039(00)78176-7