N₄-(benzo[d]oxazol-2(3H)-on-5-yl)-N₂-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt

Base Information

• Chemical Name: N₄-(benzo[d]oxazol-2(3H)-on-5-yl)-N₂-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt
• CAS No.: 1236670-89-5
• Molecular Formula: C₂HF₃O₂*C₁₉H₁₇N₅O₄S
• Molecular Weight: 525.465
• Mol file: 1236670-89-5.mol

Synonyms:N₄-(benzo[d]oxazol-2(3H)-on-5-yl)-N₂-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt

Chemical Property of N₄-(benzo[d]oxazol-2(3H)-on-5-yl)-N₂-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₄-(benzo[d]oxazol-2(3H)-on-5-yl)-N₂-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt

There total 3 articles about N₄-(benzo[d]oxazol-2(3H)-on-5-yl)-N₂-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-chloro-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-4-pyrimidineamine (1236670-87-3) + 3-methylsulfonylaniline hydrochloride (80213-28-1) + trifluoroacetic acid (76-05-1) → N4-(benzo[d]oxazol-2(3H)-on-5-yl)-N2-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt (1236670-89-5)

Guidance literature:

In isopropyl alcohol; at 85 - 90 ℃; for 40h; closed vial;

Reference yield:

5-amino-2-benzoxazolinone (14733-77-8) → N4-(benzo[d]oxazol-2(3H)-on-5-yl)-N2-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt (1236670-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: water; methanol / 64 h / 20 °C

2: isopropyl alcohol / 40 h / 85 - 90 °C

In methanol; water; isopropyl alcohol;

Reference yield:

2,6-dichloro-5-methylpyrimidine (1780-31-0) → N4-(benzo[d]oxazol-2(3H)-on-5-yl)-N2-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt (1236670-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: water; methanol / 64 h / 20 °C

2: isopropyl alcohol / 40 h / 85 - 90 °C

In methanol; water; isopropyl alcohol;

upstream raw materials:

2-chloro-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-4-pyrimidineamine

3-methylsulfonylaniline hydrochloride

trifluoroacetic acid

5-amino-2-benzoxazolinone