ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate

Base Information

• Chemical Name: ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate
• CAS No.: 125803-43-2
• Molecular Formula: C₁₄H₁₅N₅O₃
• Molecular Weight: 301.305

Synonyms:ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate

Chemical Property of ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate

Chemical Property:

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Technology Process of ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate

There total 1 articles about ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl 6-(bromomethyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (14758-00-0) → ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate (125803-43-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium azide; for 72h; Ambient temperature;

Reference yield: 88.0%

ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate (125803-43-2) + triphenylphosphine (603-35-0) → ethyl 2-oxo-4-phenyl-6-[(triphenyl-λ5-phosphanylidene)aminomethyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1199944-31-4)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1134/S1070428009060207

Reference yield: 80.0%

ethyl (+/-)-6-(azidomethyl)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate (125803-43-2) → ethyl 6-(aminomethyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (933746-13-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; Reflux;

DOI:10.1080/00397911.2012.707738

upstream raw materials:

ethyl 6-(bromomethyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Downstream raw materials:

ethyl (+/-)-6-cyano-1,2,3,4-tetrahydro-2-oxo-4-phenyl-5-pyrimidinecarboxylate

ethyl (+/-)-1,2,3,4-tetrahydro-2-oxo-4-phenyl-6-(1H-tetrazol-5-yl)-5-pyrimidinecarboxylate

ethyl 2-oxo-4-phenyl-6-[(triphenyl-λ5-phosphanylidene)aminomethyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

ethyl 6-(aminomethyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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