2-AMINO-6-TERT-BUTYL-4,5,6,7-TETRAHYDRO-BENZO[ B ]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-AMINO-6-TERT-BUTYL-4,5,6,7-TETRAHYDRO-BENZO[ B ]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 351980-73-9
• Molecular Formula: C₁₅H₂₃NO₂S
• Molecular Weight: 281.419
• Mol file: 351980-73-9.mol

Synonyms:2-amino-6-tert-butyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester

Chemical Property of 2-AMINO-6-TERT-BUTYL-4,5,6,7-TETRAHYDRO-BENZO[ B ]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-amino-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-AMINO-6-TERT-BUTYL-4,5,6,7-TETRAHYDRO-BENZO[ B ]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

There total 1 articles about 2-AMINO-6-TERT-BUTYL-4,5,6,7-TETRAHYDRO-BENZO[ B ]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

4-tercbutyl-cyclohexanone (98-53-3) + ethyl 2-cyanoacetate (105-56-6) → 2-amino-6-tert-butyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester (351980-73-9)

Guidance literature:

With morpholine; sulfur; In ethanol; at 85 ℃; for 5h;

DOI:10.1021/acs.jafc.8b00017

Reference yield:

2-amino-6-tert-butyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester (351980-73-9) + 4-Bromophenyl isothiocyanate (1985-12-2) → C20H21BrN2OS2

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃;

DOI:10.1016/j.bmcl.2017.05.030

Reference yield:

2-amino-6-tert-butyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester (351980-73-9) + phenyl isothiocyanate (103-72-0) → C20H22N2OS2 (312625-72-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃;

DOI:10.1016/j.bmcl.2017.05.030

upstream raw materials:

4-tercbutyl-cyclohexanone

ethyl 2-cyanoacetate