(4-chlorophenyl)chloromethyl isocyanate

Base Information

• Chemical Name: (4-chlorophenyl)chloromethyl isocyanate
• CAS No.: 41464-88-4
• Molecular Formula: C₈H₅Cl₂NO
• Molecular Weight: 202.04
• Mol file: 41464-88-4.mol

Synonyms:(4-chlorophenyl)chloromethyl isocyanate

Chemical Property of (4-chlorophenyl)chloromethyl isocyanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-chlorophenyl)chloromethyl isocyanate

There total 2 articles about (4-chlorophenyl)chloromethyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-(4-chloro-benzylidene)-bis-carbamic acid diethyl ester (92018-97-8) → (4-chlorophenyl)chloromethyl isocyanate (41464-88-4)

Guidance literature:

With phosphorus pentachloride; In benzene; for 4h; Heating;

DOI:10.1055/s-2006-926241

Reference yield:

4-chlorobenzaldehyde (104-88-1) → (4-chlorophenyl)chloromethyl isocyanate (41464-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / 0.25 h / 150 - 160 °C

2: PCl₅ / benzene / 4 h / Heating

With phosphorus pentachloride; sulfuric acid; In benzene;

DOI:10.1055/s-2006-926241

Reference yield: 84.0%

(4-chlorophenyl)chloromethyl isocyanate (41464-88-4) + dimedone (126-81-8) → 7,7-dimethyl-4-(4-chlorophenyl)-4,6,7,8-tetrahydro-2H-1,3-benzoxazine-2,5(3H)-dione

Guidance literature:

In toluene; at 20 ℃; for 24h;

DOI:10.1134/S1070428007020170

upstream raw materials:

N,N'-(4-chloro-benzylidene)-bis-carbamic acid diethyl ester

4-chlorobenzaldehyde

Downstream raw materials:

5-methoxycarbonyl-6-methyl-4-(4-chlorophenyl)-3,4-dihydropyrimidin-2(1H)-one

9-(4-chlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-2H,5H-1,8-acridinedione

rac-4-(4-chlorophenyl)-6-[(4-methylphenyl)imino]-3,4-dihydro[1,3,5]triazino[2,1-a]isoindol-2(6H)-one

rac-4-(4-chlorophenyl)-6-[(2,6-dimethylphenyl)imino]-3,4-dihydro[1,3,5]triazino[2,1-a]isoindol-2(6H)-one