(R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol

Base Information

Chemical Name:(R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol
CAS No.:103563-35-5
Molecular Formula:C₁₇H₂₈O₃Si
Molecular Weight:308.493
Hs Code.:

Synonyms:(R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol

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Technology Process of (R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol

There total 6 articles about (R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103563-34-4
Methanesulfonic acid (Z)-(S)-5-benzyloxymethoxy-1-methyl-2-oxo-3-trimethylsilanyl-pent-3-enyl ester

: 103563-35-5
(R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol

Guidance literature:: With triethylaluminum; diisobutylaluminium hydride; Multistep reaction; 1.) CH₂Cl₂, -78 deg C;
DOI:10.1016/S0040-4039(00)89229-1

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 103563-35-5
(R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: NaH

2: EtMgBr

3: DIBAL, Br₂

4: 92 percent / n-BuLi / tetrahydrofuran; diethyl ether; hexane / 0.5 h

5: Et₃N / CH₂Cl₂ / 0.33 h / -45 °C

6: DIBAL, Et₃Al / CH₂Cl₂ / 2 h / -78 - -20 °C

With n-butyllithium; ethylmagnesium bromide; bromine; triethylaluminum; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja00277a028

Reference yield:

: 96011-46-0
3-(benzyloxymethoxy)prop-1-yne

: 103563-35-5
(R)-(Z)-5-<(benzyloxy)methoxy>-2-methyl-3-(trimethylsilyl)-3-penten-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: EtMgBr

2: DIBAL, Br₂

3: 92 percent / n-BuLi / tetrahydrofuran; diethyl ether; hexane / 0.5 h

4: Et₃N / CH₂Cl₂ / 0.33 h / -45 °C

5: DIBAL, Et₃Al / CH₂Cl₂ / 2 h / -78 - -20 °C

With n-butyllithium; ethylmagnesium bromide; bromine; triethylaluminum; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja00277a028