1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone

Base Information

• Chemical Name: 1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone
• CAS No.: 107223-60-9
• Molecular Formula: C₂₁H₂₄N₄O₃
• Molecular Weight: 380.447

Synonyms:1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone

Chemical Property of 1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone

Chemical Property:

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Technology Process of 1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone

There total 6 articles about 1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

[4-(4-Acetyl-2-butyl-3-hydroxy-benzyloxy)-phenyl]-acetonitrile (107223-52-9) → 1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone (107223-60-9)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 105 ℃; for 20h;

DOI:10.1021/jm00388a028

Reference yield:

4-cyanomethylphenol (14191-95-8) → 1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone (107223-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaOEt, 2.) NaI / 1.) EtOH, 0.25 h, 2.) EtOH, RT, 48 h

2: 68 percent / NaN₃, NH₄Cl / dimethylformamide / 20 h / 105 °C

With sodium azide; sodium ethanolate; ammonium chloride; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00388a028

Reference yield:

1-(3-Butyl-4-chloromethyl-2-hydroxy-phenyl)-ethanone (107223-43-8) → 1-{3-Butyl-2-hydroxy-4-[4-(1H-tetrazol-5-ylmethyl)-phenoxymethyl]-phenyl}-ethanone (107223-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaOEt, 2.) NaI / 1.) EtOH, 0.25 h, 2.) EtOH, RT, 48 h

2: 68 percent / NaN₃, NH₄Cl / dimethylformamide / 20 h / 105 °C

With sodium azide; sodium ethanolate; ammonium chloride; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00388a028

upstream raw materials:

[4-(4-Acetyl-2-butyl-3-hydroxy-benzyloxy)-phenyl]-acetonitrile

4-cyanomethylphenol

1-(3-Butyl-4-chloromethyl-2-hydroxy-phenyl)-ethanone

1-(3-Butyl-4-dimethylaminomethyl-2-hydroxy-phenyl)-ethanone

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