2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester

Base Information

Chemical Name:2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester
CAS No.:219475-92-0
Molecular Formula:C₁₅H₁₄N₂O₅
Molecular Weight:302.287
Hs Code.:

Synonyms:2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester

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Chemical Property of 2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester

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Technology Process of 2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester

There total 3 articles about 2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 53326-58-2
cis-1,4-bis(trimethylsilyloxy)-2-butene

: 219475-80-6
2-Diazo-5,5-dimethoxy-3-oxo-pentanoic acid phenyl ester

: 219475-92-0
2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -15 ℃; for 20h;
DOI:10.1016/S0040-4039(98)01987-X

Reference yield:

: 112306-15-7
phenyl 2-diazo-3-oxobutanoate

: 219475-92-0
2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

2: BF₃*Et₂O / CH₂Cl₂ / 3.5 h / -78 °C

3: 82 percent / TMSOTf / CH₂Cl₂ / 20 h / -15 °C

With trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)01987-X

Reference yield:

: 2-Diazo-3-trimethylsilanyloxy-but-3-enoic acid phenyl ester

: 219475-92-0
2-Diazo-4-(4,7-dihydro-[1,3]dioxepin-2-yl)-3-oxo-butyric acid phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: BF₃*Et₂O / CH₂Cl₂ / 3.5 h / -78 °C

2: 82 percent / TMSOTf / CH₂Cl₂ / 20 h / -15 °C

With trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1016/S0040-4039(98)01987-X