Technology Process of N,N,2-trimethyl-3-[(4-methylphenyl)sulfonyl]-2',3',6,7-tetrahydro-3H-spiro[chromeno[7,8-d]imidazole-8,1'-indene]-5-carboxamide
There total 7 articles about N,N,2-trimethyl-3-[(4-methylphenyl)sulfonyl]-2',3',6,7-tetrahydro-3H-spiro[chromeno[7,8-d]imidazole-8,1'-indene]-5-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
o-xylene;
at 150 ℃;
for 10h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: iron; acetic acid / 6 h / Heating / reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C
2.2: 0.5 h / 0 - 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 32 h / 65 °C
3.2: 20 °C
4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 h / 20 °C / 760.05 Torr
5.1: dichloromethane / 15 h / 40 °C
5.2: 20 °C
6.1: o-xylene / 10 h / 150 °C
With
hydrogen; iron; sodium hydride; acetic acid;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; o-xylene; N,N-dimethyl-formamide;
5.1: Mannich Reaction;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / 0.33 h / 70 °C
2.1: iron; acetic acid / 6 h / Heating / reflux
3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C
3.2: 0.5 h / 0 - 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 32 h / 65 °C
4.2: 20 °C
5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 h / 20 °C / 760.05 Torr
6.1: dichloromethane / 15 h / 40 °C
6.2: 20 °C
7.1: o-xylene / 10 h / 150 °C
With
hydrogen; iron; sodium hydride; acetic acid;
tetrakis(triphenylphosphine) palladium(0); sulfuric acid; palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; o-xylene; N,N-dimethyl-formamide;
6.1: Mannich Reaction;