1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylicacid,(S)-(9CI)

Base Information

• Chemical Name: 1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylicacid,(S)-(9CI)
• CAS No.: 75776-51-1
• Molecular Formula: C7H11 N O4
• Molecular Weight: 173.169
• Mol file: 75776-51-1.mol

Synonyms:1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylicacid,(S)-(9CI)

Chemical Property of 1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylicacid,(S)-(9CI)

Chemical Property:

• PSA: 67.79000
• LogP: -0.49520

Purity/Quality:

99% ^*data from raw suppliers

(S)-1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylicacid,(S)-(9CI)

There total 2 articles about 1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylicacid,(S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-aza-1,4-dioxaspiro<4.4>nonane-7,8-dicarboxylic acid 7-(phenylmethyl ester) (75776-49-7) → (8S)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid (75776-51-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00401a014

Reference yield:

1-benzyloxycarbonyl-4-keto-L-proline (64187-47-9) → (8S)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid (75776-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / benzene / 7 h / Heating

2: H₂ / 5percent Pd/C / methanol

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; benzene;

DOI:10.1021/jm00401a014

Reference yield:

(2R,S)-3-Acetylthio-2-methylpropanoyl chloride (74345-73-6) + (8S)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid (75776-51-1) → (S)-7-((S)-3-Acetylsulfanyl-2-methyl-propionyl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid

Guidance literature:

With sodium carbonate; In water; for 1h;

DOI:10.1021/jm00401a014

upstream raw materials:

7-aza-1,4-dioxaspiro<4.4>nonane-7,8-dicarboxylic acid 7-(phenylmethyl ester)

1-benzyloxycarbonyl-4-keto-L-proline

Refernces

• 1、 -. "DERIVATIVES OF MERCAPTOACYL PROLINES AND PIPECOLIC ACIDS". . . Retrieved 2008/06/13.