N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

Base Information

Chemical Name:N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide
CAS No.:1309111-17-8
Molecular Formula:C₂₆H₁₆ClF₆N₃O₅
Molecular Weight:599.874
Hs Code.:

Synonyms:N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

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Chemical Property of N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

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Technology Process of N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

There total 7 articles about N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309111-02-1
N-[1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

: 1309111-19-0
N-[(1R)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

: 1309111-17-8
N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

Guidance literature:: With Chiralpak IC; In ethanol; n-heptane; dichloromethane; Resolution of racemate;

Reference yield:

: 1228695-06-4
3-(2-amino-2-cyano-2-methyl-ethoxy)-4-(2-chloro-4-trifluoromethoxy-phenoxy)-benzonitrile

: 1309111-19-0
N-[(1R)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

: 1309111-17-8
N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

2: Chiralpak IC / dichloromethane; n-heptane; ethanol / Resolution of racemate

With N-ethyl-N,N-diisopropylamine; In ethanol; n-heptane; dichloromethane;

Reference yield:

: 1309111-06-5
4-{2-chloro-4-trifluoromethoxy-phenoxy}-3-methoxy-benzonitrile

: 1309111-19-0
N-[(1R)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

: 1309111-17-8
N-[(1S)-1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 20.5 h / 10 - 20 °C

1.2: Cooling with ice

2.1: potassium carbonate; potassium iodide / acetone / 4 h / Reflux

3.1: ammonia; ammonium chloride / ethanol; water / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

5.1: Chiralpak IC / dichloromethane; n-heptane; ethanol / Resolution of racemate

With ammonia; boron tribromide; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In ethanol; n-heptane; dichloromethane; water; acetone;