(1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

Base Information

Chemical Name:(1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate
CAS No.:1219138-76-7
Molecular Formula:C₁₆H₁₄ClNO₃
Molecular Weight:303.745
Hs Code.:

Synonyms:(1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

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Technology Process of (1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

There total 4 articles about (1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1219138-77-8
methyl propargylcyanoacetate

: 1075-77-0
4-chlorocinnamaldehyde

: 1219138-76-7
(1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

: methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

Guidance literature:: methyl propargylcyanoacetate; With silica supported chiral amine-diaminopalladium complex; In chloroform; at 20 ℃; for 0.0833333h; Inert atmosphere;

4-chlorocinnamaldehyde; In chloroform; at 20 ℃; for 24h; stereoselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201400291

Reference yield:

: 1219138-77-8
methyl propargylcyanoacetate

: 1075-77-0
4-chlorocinnamaldehyde

: methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

: 1219138-76-7
(1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

Guidance literature:: With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; In toluene; at 20 ℃; Overall yield = 61 %; enantioselective reaction;
DOI:10.1002/anie.201310216

Reference yield:

: 1219138-77-8
methyl propargylcyanoacetate

: 1075-77-0
4-chlorocinnamaldehyde

: 1219138-76-7
(1R,2R)-methyl 2-(4-chlorophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate

: C₁₆H₁₄ClNO₃

Guidance literature:: methyl propargylcyanoacetate; In toluene; at 20 ℃; for 0.0833333h;

4-chlorocinnamaldehyde; With C₂₀H₂₇NSi; In toluene; at 20 ℃; for 24h; Overall yield = 72 %; enantioselective reaction;
DOI:10.1002/adsc.201500100