(7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one

Base Information

Chemical Name:(7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one
CAS No.:1421050-80-7
Molecular Formula:C₃₁H₄₁ClN₂O₅
Molecular Weight:557.13
Hs Code.:

(7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one

Synonyms:(7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one

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Chemical Property of (7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one

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Technology Process of (7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one

There total 8 articles about (7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421050-68-1
C₃₃H₄₅ClN₂O₅

: 1421050-80-7
(7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol3032126

Reference yield:

: C₂₂H₂₉NO₃

: 1421050-80-7
(7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: sodium cyanoborohydride; acetic acid / ethanol / 1 h / 0 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h

4: dichloromethane / 0.17 h / 0 °C

5: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 10 h / 0 - 20 °C

6: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 24 h / 40 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol3032126

Reference yield:

: 1421050-48-7
C₂₀H₃₄N₂O₄

: 1421050-80-7
(7S,11S,12S,E)-6-(4-chlorobenzoyl)-9-isobutyl-7-isopropyl-11,12-dimethoxy-6,7,9,10,11,12-hexahydro-2H-benzo[m][1,6,9]oxadiazacyclotetradecin-8(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 0.17 h / 0 °C

2: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 10 h / 0 - 20 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 24 h / 40 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol3032126