N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester

Base Information

Chemical Name:N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester
CAS No.:164364-24-3
Molecular Formula:C₂₀H₃₀N₂O₅
Molecular Weight:378.469
Hs Code.:

Synonyms:N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester

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Chemical Property of N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester

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Technology Process of N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester

There total 4 articles about N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: 151927-75-2
2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoic acid

: 164364-24-3
N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) 0 deg C, 1 h, 2.) 20 deg C, 48 h;
DOI:10.1021/jm00012a011

Reference yield:

: 759-36-4
diethyl isopropylmalonate

: 164364-24-3
N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / ethanol

2: HOBT, DCC / CH₂Cl₂ / 1.) 5 deg C, 1 h, 2.) 20 deg C, 68 h

3: KOH, water / ethanol / 18 h

4: 67 percent / DCC, HOBT-H₂O, iPr₂NEt / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 20 deg C, 48 h

With potassium hydroxide; water; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a011

Reference yield:

: potassium 2-(ethoxycarbonyl)-3-methylbutanoate

: 164364-24-3
N-<2-<<(phenylmethoxy)amino>carbonyl>-3-methylbutanoyl>-β-alanine 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HOBT, DCC / CH₂Cl₂ / 1.) 5 deg C, 1 h, 2.) 20 deg C, 68 h

2: KOH, water / ethanol / 18 h

3: 67 percent / DCC, HOBT-H₂O, iPr₂NEt / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 20 deg C, 48 h

With potassium hydroxide; water; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a011