(E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid

Base Information

Chemical Name:(E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid
CAS No.:1308279-89-1
Molecular Formula:C₂₆H₂₇NO₄
Molecular Weight:417.505
Hs Code.:

Synonyms:(E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid

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Chemical Property of (E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid

Chemical Property:

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Technology Process of (E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid

There total 6 articles about (E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1308279-85-7
(E)-3-{2-[3'-(1-adamantyl)-4'-hydroxyphenyl]-5-pyridinyl}-2-propenoic acid

: 108-24-7
acetic anhydride

: 1308279-89-1
(E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid

Guidance literature:: With dmap; In tetrahydrofuran; for 27h; Inert atmosphere;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1308279-89-1
(E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / Reflux

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 92 °C

3.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: pH 7 - 8 / Inert atmosphere

4.1: sodium hydroxide; water / methanol / 1.5 h / 86 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: dmap / tetrahydrofuran / 27 h / Inert atmosphere

With dmap; water; boron tribromide; sodium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;

Reference yield:

: 656827-74-6
ethyl (E)-3-(6-bromo-3-pyridinyl)-2-propenoate

: 1308279-89-1
(E)-3-{2-[3'-(1-adamantyl)-4'-acetoxyphenyl]-5-pyridinyl}-2-propenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 92 °C

2.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

2.2: pH 7 - 8 / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 1.5 h / 86 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: dmap / tetrahydrofuran / 27 h / Inert atmosphere

With dmap; water; boron tribromide; sodium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;