4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid

Base Information

Chemical Name:4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid
CAS No.:103004-01-9
Molecular Formula:C₁₇H₁₉N₅O₂
Molecular Weight:325.37
Hs Code.:

Synonyms:4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid

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Chemical Property of 4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid

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Technology Process of 4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid

There total 3 articles about 4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 103004-00-8
methyl 4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroate

: 103004-01-9
4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid

Guidance literature:: With sodium hydroxide; In 2-methoxy-ethanol; water; 1.) 22 deg C, 6 h, 2.) 5 deg C, 15 h;
DOI:10.1021/jm00159a039

Reference yield:

: 103003-98-1
methyl 4-amino-4-deoxy-5,10-carbonyl-5,6,7,8-tetrahydro-8,10-dideazapteroate

: 103004-01-9
4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1 M BH₃, 2.) HCl (gas) / 1.) THF, 22 deg C, 22 h, 2.) MeOH, 0 deg C

2: 75 percent / NaOH / 2-methoxy-ethanol; H₂O / 1.) 22 deg C, 6 h, 2.) 5 deg C, 15 h

With hydrogenchloride; sodium hydroxide; borane; In 2-methoxy-ethanol; water;
DOI:10.1021/jm00159a039

Reference yield:

: 103003-97-0
dimethyl 4-amino-4-deoxy-10-carboxytetrahydro-8,10-dideazapteroate

: 103004-01-9
4-amino-4-deoxy-5,10-methylene-5,6,7,8-tetrahydro-8,10-dideazapteroic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 0.75 h / 175 - 180 °C

2: 1.) 1 M BH₃, 2.) HCl (gas) / 1.) THF, 22 deg C, 22 h, 2.) MeOH, 0 deg C

3: 75 percent / NaOH / 2-methoxy-ethanol; H₂O / 1.) 22 deg C, 6 h, 2.) 5 deg C, 15 h

With hydrogenchloride; sodium hydroxide; borane; In 2-methoxy-ethanol; water;
DOI:10.1021/jm00159a039