2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine

Base Information

Chemical Name:2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine
CAS No.:1013403-74-1
Molecular Formula:C₂₆H₂₇F₂N₇O
Molecular Weight:491.543
Hs Code.:

Synonyms:2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine

Suppliers and Price of 2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine

There total 5 articles about 2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₅F₂N₇O₃

: 1013403-74-1
2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine

Guidance literature:: C₃₁H₃₅F₂N₇O₃; With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃;

With ammonia; In methanol;

Reference yield:

: 1012317-17-7
1-[4-chloro-6-(morpholin-4-yl)pyrimidin-2-yl]-2-(difluoromethyl)-1H-benzimidazole

: 1013403-74-1
2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 120 °C / microwave irradiation

2: hydrogenchloride; water / 1,4-dioxane / 20 °C

With hydrogenchloride; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water;

Reference yield:

: 52127-83-0
4-(2,6-dichloropyrimidin-4-yl)morpholine

: 1013403-74-1
2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholino-4-(4-piperazin-1-ylphenyl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 120 °C / microwave irradiation

3: hydrogenchloride; water / 1,4-dioxane / 20 °C

With hydrogenchloride; water; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;