Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate

Base Information

Chemical Name:Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate
CAS No.:135363-71-2
Molecular Formula:C₂₉H₃₆Cl₂N₂O₄
Molecular Weight:547.522
Hs Code.:

Synonyms:Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate

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Chemical Property of Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate

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Technology Process of Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate

There total 5 articles about Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 135363-64-3
tert-Butyl 3-(2-Chloroethyl)-1,4-dimethylpyrrole-2-carboxylate

: 37945-74-7
benzyl 5-acetoxymethyl-4-(2-chloroethyl)-3-methylpyrrole-2-carboxylate

: 135363-71-2
Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In acetic acid; at 45 ℃;

Reference yield:

: 51089-77-1
Benzyl 5-tert-Butoxycarbonyl-4-(2-chloroethyl)-3-methylpyrrole-2-carboxylate

: 135363-71-2
Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) KOH / 1.) DMSO, 1.5 h, 2.) 2 h

2: H₂, N(C₂H₅)3 / 5percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature

3: NaHCO₃, I₂, KI / methanol; H₂O / 1 h / 60 °C

4: 98 percent / sodium acetate, H₂ / Adams' platinum oxide catalyst / methanol / 20 °C / 760 Torr

5: 67 percent / toluene-p-sulphonic acid hydrate / acetic acid / 45 °C

With potassium hydroxide; hydrogen; iodine; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; potassium iodide; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetic acid;

Reference yield:

: 135383-00-5
tert-Butyl 3-(2-Chloroethyl)-1,4-dimethyl-5-iodopyrrole-2-carboxylate

: 135363-71-2
Benzyl 5'-tert-Butoxycarbonyl-3,4'-bis(2-chloroethyl)-1',3',4-trimethyldipyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / sodium acetate, H₂ / Adams' platinum oxide catalyst / methanol / 20 °C / 760 Torr

2: 67 percent / toluene-p-sulphonic acid hydrate / acetic acid / 45 °C

With hydrogen; sodium acetate; toluene-4-sulfonic acid; platinum(IV) oxide; In methanol; acetic acid;